Kymab Announces Positive Phase 2a Results for KY1005 in Moderate to Severe Atopic Dermatitis

Kymab, a clinical-stage biopharmaceutical company developing fully human monoclonal antibodies with a focus on immune-mediated diseases and immuno-oncology therapeutics, announced today that the primary endpoints in its Phase 2a (NCT03754309), randomized, double-blinded, placebo-controlled study have been met.

• KY1005 met both primary end points demonstrating:
  • A clinically meaningful improvement in disease activity compared to placebo, as measured by percentage of change from baseline in the Eczema Area and Severity Index (EASI) in patients inadequately controlled by topical corticosteroids from baseline to week 16
  • Safety with an acceptable adverse event and tolerability profile
• KY1005 is a fully human monoclonal antibody that has a novel mechanism of action, it binds to OX40-Ligand (OX40L) and has the potential to treat a wide variety of immune-mediated diseases and inflammatory disorder

 

Cambridge, UK, 11 August 2020: Kymab, a clinical-stage biopharmaceutical company developing fully human monoclonal antibodies with a focus on immune-mediated diseases and immuno-oncology therapeutics, announced today that the primary endpoints in its Phase 2a (NCT03754309), randomized, double-blinded, placebo-controlled study have been met.